郭敏玲 教授

Prof. Ming-Ling Kuo

中心合聘人員

分子免疫研究室

Laboratory of Molecular Immunology, Department of Microbiology and Immunology, Chang Gung University

學歷

1988-1994 PH.D. in Microbiology and Molecular Genetics, Rutgers

University/Molecular Genetics and Microbiology, University of

Medicine and Dentistry of New Jersey.

1986-1988 M.S. in Medical Microbiology and Immunology, The Ohio State

University.

1981-1985 國立台灣大學農業化學系農產製造組學士

經歷

2022.8-至今 長庚大學醫學院生物醫學研究所 所長

2010.8-至今 長庚大學醫學院生物醫學研究所/微生物暨免疫學科 教授

2016.8-2019.7 長庚大學研發處 研發長

2009.8-2016.7 長庚大學醫學院微生物免疫學科 主任

2015.8-2016 .7長庚大學教務處研究生教務組 組長

2002-2010 長庚大學醫學院生物醫學研究所/微免科 副教授

1996-2004 長庚兒童醫院兒童健康研究部 技術主任

1997-2002 長庚大學醫學院基研所/微免科 兼任副教授

1996-2002 長庚醫院醫學研究中心 副研究員

1994-1996 台大醫院肝炎研究中心 博士後研究員

1989-1994 Dept. of Microbiology and Molecular Genetics, University of

Medicine and Dentistry of New Jersey. Research assistant

1987-1988 Dept. of Medical Microbiology and Immunology, The Ohio

State University. Research assistant

1985-1986 國防醫學院生化學科 專任助教

榮譽

2021-2024 科技部創新轉譯主軸推動研究計畫

2013.09 優良教師-教學獎，長庚大學

2012.11 傑出學者獎， 中華民國免疫學會

2002-2006 Career Development Grant Award, National Health Research

Institute, Taiwan.

1988-1989 Excellence fellowship, Graduate School-New Brunswick, Rutgers

University.

研究方向

過敏相關疾病為研究主軸，研究疾病的分子機制及開發新療法

氣喘病之基因治療

藥物或是抗體引發調節T細胞的發展

探討可治療氣喘中藥之科學證據

臍帶血淋巴細胞活性研究

探討以不同細胞激素組合對臍帶血中 T 輔助細胞及自然殺手細胞之複製、死亡及活性的調控

研究論文(選錄)

• Chiang P-C, Chen J-C, Chen L-C, Kuo M-L*. Adeno-associated virus-mediated interleukin12 gene expression alleviates lung inflammation and type 2 T-helper-responses in ovalbumin-sensitized asthmatic mice. Hum. Gene Ther. 2022; 33: 1052-1061. (DOI:10.1089/hum.2022.034)
• Ting N-C, Chen Y-H, Chen J-C, Huang W-C, Liou C-J, Chen L-C, Yang S-H‡, Kuo M-L‡.Perilla fruit water extract attenuates inflammatory responses and alleviates neutrophilrecruitment via MAPK/JNK-AP-1/c-Fos signaling pathway in ARDS animal model. eCAM 2022; 2022: 4444513, 12 pages. (DOI:10.1155/2022/4444513)
• Lai Y-R, Chang Y-F, Ma J, Chiu C-H, Kuo M-L‡, Lai C-H‡. From DNA damage to cancerprogression: potential effects of cytolethal distending toxin. Front. Immunol. 2021; 2021: 12(DOI: 10.3389/fimmu.2021.760451)
• Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai SH, Yao T-S, Yeh K-W, Wu A-H, Yu H-Y, Huang J-L, Huang S-K. Levels of 15-HETE and TXB in exhaled breadth condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr. Allergy Immunol. 2021; 32: 1673-1680 (DOI:10.1111/pai.13587.)
• Ma J, Liu M-X, Chen L-C, Shen J-J, Kuo M-L* Ding Chuan Tang attenuates airway inflammation and eosinophil infiltration in ovalbumin-sensitized asthmatic mice. Biomed. Res. Int. 2021; 2021: 6692772, 10 pages. (DOI: 10.1155/2021/6692772)
• Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L‡. Yao T-C‡. Particulate mattercauses telomere shortening and cellular senescence in human lung epithelial cells. Ecotox Environ Safe. 2021. 222: 112484-112492. (DOI: 10.1016/j.ecoenv.2021.112484)
• 7. Chen J-C, Chan C-C, Ting N-C, Kuo M-L*. Allergen exposure in murine neonates promoted the development of allergic lungs. Biomedicines. 2021; 9: 688-703. (DOI: 10.3390/biomedicines9060688)
• Huang Y-A, Chen J-C, Wu C-C, Hsu C-W, Ko Albert M-S, Chen L-C, Kuo M-L*. Reducing lung ATP levels and alleviating asthmatic airway inflammation through adeno-associated viral vector-mediated CD39 expression. Biomedicines. 2021; 9: 656-669. (DOI:10.3390/biomedicines9060656)
• Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L, Chen S-C, Chui C-H. Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines. 2021; 9: 245-260. (DOI: 10.3390/biomedicines9030245)
• Chen Y-W, Huang M-Z, Chen C-L, Kuo C-Y, Yang C-Y, Ni-Chiang C, Chen Y-Y, Hsieh CM, Wu H-Y, Kuo M-L, Chiu C-H, Lai C-H. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part. Fibre. Toxicol. 2020; 17:37-51. (DOI: 10.1186/s12989-020-00362-2.)
• Khan M, Huang Y-A, Kuo C-Y, Lin T, Lu C-H, Chen L-C, Kuo M-L*. Blocking pannexin1 reduces airway inflammation in a murine model of asthma. Am. J. Transl. Res. 2020; 12:4074-4083. (PMCID: PMC7407700)
• Ma J, Chan C-C, Huang W-C, Kuo M-L*. Berberine inhibits pro-inflammatory cytokineinduced IL-6 and CCL11 production via modulation of STAT6 pathway in human bronchial epithelial cells. Int. J. Med. Sci. 2020; 17: 1464-1473. (DOI: 10.7150/ijms.45400)
• Lu C-H, Chen C-M, Ma J, Wu C-J, Chen L-I, Kuo M-L*. DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation. Int. Immunopharmacol. 2020; 84:106542. (DOI:10.1016/j.intimp.2020.106542)
• Lin T-C, Kuo C-C, Wu C-Y, Yeh K-W, Kuo M-L‡, Huang J-L‡. The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: a retrospective cohort study. J.Microbiol. Immunol. Infect. 2020; 53: 797-802. (DOI: 10.1016/j.jmii.2018.12. 003)
• Wu C-J, Cho S, Huang H-Y, Lu C-H, Russ J, Cruz L-O, Cunha da Cunha F-F, Chen M-C, Lin L-L, Warner L-M, Liao H-K, Utzschneider D-T, Quon S, Berner J, Camara N-O-S, Zehn D, Belmonte J-C-I, Chen L-C, Huang S-K, Kuo M-L, Lu L-F. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci. Adv. 2019; 5: eaaw1715. (DOI: 10.1126/sciadv.aaw1715)
• Ting N-C, Hung W-C, Chen L-C, Yang S-H, Kuo M-L*. Descurainia sophia water extract ameliorates eosinophil infiltration and airway hyperresponsiveness by reducing Th2 cytokine production in asthmatic mice. Am. J. Chin. Med. 2019; 47: 1507-1522. (DOI:10.1142/S0192415X19500770.)
• Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T, Lee W-I, Chen J-Y, Huang J-L. Cytotoxic function and cytokine production of natural killer cells and natural killer T-like cells in systemic lupus erythematosis-regulation with interleukin-15. Mediat. Inflamm. 2019; 2019: 4236562, 12 pages. (DOI:10.1155/2019/4236562)
• Wu C-J, Tseng P-H, Chan C-C, Sara Quon, Chen L-C, Kuo M-L*. OK-432 acts as adjuvant to modulate T helper 2 inflammatory responses in a murine model of asthma. J. Immunol. Res. 2018; 2018: 1-9. (DOI: 10.1155/2018/1697276)
• Chen J-C, Ou L-S, Chan C-C, Kuo M-L, Tseng L-Y, Chang H-L. In utero exposure to exosomal and B-cell alloantigens lessens alloreactivity of recipients’ lymphocytes rather than confers allograft tolerance. Front. Immunol. 2018. 9: 418-426. (DOI: 10.3389/fimmu.2018.00418)
• Kuo C-Y, Huang W-C, Liou C-J, Chen L-C, Shen J-J, Kuo M-L*. Tomatidine attenuates airway hyperresponsiveness and inflammation by suppressing Th2 cytokines in a mouse model of asthma. Mediat. Inflamm. 2017; 4: 5261803. (DOI 10.1155/2017/5261803)